LRP5 and parathyroid gland adenoma: Other factors related to both Wnt signaling pathway and parathyroid adenoma pathogenesis are the following: (a) LRP5 gene, which is associated with β-catenin destruction complex and is found in 86% in parathyroid adenomas, (b) APC gene, methylated in parathyroid adenomas and (c) RASSF1A gene, which is hypermethylated and underexpressed in parathyroid adenomas in 71% (11, 14).