Among 156 differentially expressed genes and FDR-adjusted p-value <0.05, We have retrieved a set TMEM173 and CHUK mRNAs according to the following criteria: (i) Genes which are dysregulated in T2DM and insulin resistance molecular pathways; (ii) Genes which are expressed in tissues of interest, e.g., skeletal muscle, adipose tissue and also in blood samples for easy extraction and less invasiveness; (iii) Both genes are related to STING and NLR signaling pathway involved in innate immunity and chronic sterile inflammation; (iv). Here, CHUK is linked to type 2 diabetes mellitus.