TMEM173 variants were also found in many human diseases such as esophageal squamous cell carcinoma (18), colon cancer (19), lung diseases including familial interstitial lung disease (20), and severe pulmonary fibrosis (21) and drives lethal coagulation in sepsis (22), These findings make TMEM173 a potential therapeutic target for both cancers and inflammatory diseases. Here, STING1 is linked to esophageal squamous cell carcinoma.