Exosomes can be valuable also for a deeper investigation of PA and hypertension features: few studies have shown that uEVs cargo of patients suffering of mineralocorticoid-dependent arterial hypertension are enriched in proteins and miRNA related to salt reabsorption activity and regulation (9–11) and recently Alpha-1-Acidic Glycoprotein (A1AG1 or AGP1), found in UEVs, was proposed as potential biomarker of PA (12). The gene discussed is ORM1; the disease is hypertensive disorder.