IGF1 and Central hypothyroidism: After surgery, central hypogonadism was detected in 40.8% of patients (30% of which were postmenopausal women), central hypothyroidism in 29.3%, central adrenal insufficiency in 27.4% (22.7% with the strict analysis), and low IGF-1 in 17% of patients (Table 2 and Fig. 2).