IGF1 and Central hypothyroidism: Before surgery, central hypogonadism was detected in 62.4% of patients (31.5% of which were postmenopausal women), central hypothyroidism in 41%, central adrenal insufficiency in 30.8% (21.3% with the strict analysis), and low IGF-1 in 29.9% of patients (Table 2 and Fig. 2).