Another study found that heat shock transcription factor 1 (HSF1) accumulates in the mitochondria of HD cell models, a mouse model, and human striatal organoids derived from induced HD iPSCs, and suppressing the mitochondrial localization of HSF1 by interfering with its binding to dynamin-related protein 1 can rescue the pathological HD changes in striatal organoids [104]. Here, HSF1 is linked to Huntington disease.