With the improvement of detection technology, many gene mutations were found to be related to the prognosis of CCA, such as FGFR2 (Makawita et al. 2020), HAMP (Wang and Du 2021), GLUT-1 (Labib et al. 2019), KRAS (Dong et al. 2022), and so on. This evidence concerns the gene KRAS and cholangiocarcinoma.