In vitro, in a human PBMC model system with an influenza matrix SLP, Amplivant-SLP in virosomes, when used to stimulate human moDCs, expanded greater numbers of influenza-specific CD8 + memory T cells in PBMCs than Amplivant-SLP alone, and the presence of the additional adjuvants QS-21 and 3D-PHAD in the virosomal membrane further enhanced this antigen-specific expansion. The gene discussed is CD8A; the disease is influenza.