CASP1 and intervertebral disk degenerative disorder: Furthermore, the immunohistochemistry results revealed that the expressions of HMGB1, p65, the pyroptotic proteins NLRP3 and cleaved caspase-1, and the senescence-related protein p21 were increased in the IDD group and markedly decreased in the rosuvastatin group compared with those in the IDD group (Figure 7E‒I).