Despite previous studies in pneumococcus infections reported that neutrophil recruitment was independent of selectins (Mizgerd et al., 1996; Moreland et al., 2004), in our setting both in vitro studies and in vivo experiments with P-selectin-deficient Selp−/− mice and Ptx3−/−Selp−/− double deficient mice indicated a defective control of invasive pneumococcal infection in Ptx3−/− mice. Here, PTX3 is linked to pneumococcal infection.