(E) Bacterial load in lungs collected 36 hr post-infection from WT mice treated intranasally before the infection (prophylaxis, data pooled from two independent experiments, n = 22–26) or 12 hr post-infection (treatment, data pooled from three independent experiments, n = 37–40) with 1 μg/30 μl of recombinant PTX3 or phosphate-buffered saline (PBS). Here, PTX3 is linked to infection.