RBM20 and familial dilated cardiomyopathy: For example, Lars Steinmetz's group used a two-dimensional in vitro model of DCM to show that CRISPR-based knock-in of patient-specific mutations in RBM20 can lead to splicing defects and impaired contraction in hiPSC-derived cardiomyocytes compared to isogenic controls (Briganti et al., 2020).