It is well established that tumors promote immune cell apoptosis and paralyze antitumor immune response through the release of immune‐suppressive factors like NO, IL‐10, IL‐6, and arginase‐I, or shaping the DCs to a tumor‐suppressive phenotype.[27] The hydrogel system bypasses the suppressive microenvironment limitation by establishing a novel microenvironment favoring tumor immunotherapy. Here, IL10 is linked to neoplasm.