HMGB1 and cancer: DAMPs include the cell surface exposure of calreticulin (CRT) and heat‐shock proteins (HSP70 and HSP90), extracellular release of adenosine triphosphate (ATP), high‐mobility group box‐1 (HMGB1), type I IFNs and members of the IL‐1 cytokine family.[34] Since ultrasound can achieve deeper tissue penetration without damaging the surrounding healthy tissues, US‐triggered SDT emerges as an ideal method for cancer therapy.