TP53 and neoplasm: Mutations in subgroup-restricted genes were found; for example, one MB-WNT (P7708_102T) tumor presented with the typical CTNNB1 mutation, three (F0025678-0810, F0025679-0775, BTB0001) SHH-MB were driven by mutation/deletion of PTCH1, and two (FAM2T, P2233_111T) were driven by SUFU mutation/deletion in combination with TP53 or PTEN mutation.