HELQ and cancer: In addition to revealing somatic mutations in a broad spectrum of genes previously implicated in pediatric cancers, we discovered numerous previously unreported events, such as focal amplifications, including BORCS5 and LMO3 in an SHH-MB (FAM2T), an amplicon containing the PLAGL2 and POFUT1 genes in a sample diagnosed as MB (P4551_210T), GADL1::RBMS3 and SYNPO2::HELQ fusions in an ependymoma (P7708_109T) and a PLEKHA5::PIK3C2G fusion in a PNET (P2233_101T).