Furthermore, the highly expressed DEGs of fibroblasts in LNM included immune-related genes (CCL21, CCL19, CCL2, and MYC), metabolism-related genes (STEAP4, FABP4, DPT, and APOE), and genes related to tumor proliferation and progression (RGS, CCN, and MYC). This evidence concerns the gene PITX2 and neoplasm.