Our study showed that the proportions of STEAP4 + and ADGRF5 + fibroblasts, as well as CXCR4 + and SRGN + fibroblasts, were significantly higher in lymphatic metastases than that in primary lesions, implying that they were related to PCa progression and metastasis. This evidence concerns the gene ADGRF5 and posterior cortical atrophy.