Studies have found that CCR7 promotes tumor development by promoting tumor cell proliferation and metastasis, encouraging proteolytic enzyme secretion, and inducing angiogenesis and immunosuppression [31–36], which is consistent with our findings, where CD8 + T and other tumor immune cell levels decreased and underwent transcriptional recombination, resulting in significant immunosuppression in lymphatic metastases. The gene discussed is CCR7; the disease is neoplasm.