Casey SC et al. found that MYC contributed greatly to antitumor immunity by regulating CD47 and PD-L1 [24].Consistent with previous study, our results demonstrated that MYC, as an oncogene, does not only directly participate in tumor progression and metastasis, but also induces an immunosuppressive microenvironment through PDLI or CD47 to promote metastasis in PCa. Here, CD274 is linked to posterior cortical atrophy.