Our study showed that the proportions of STEAP4 + and ADGRF5 + fibroblasts, as well as CXCR4 + and SRGN + fibroblasts, were significantly higher in lymphatic metastases than that in primary lesions, implying that they were related to PCa progression and metastasis. The gene discussed is CXCR4; the disease is posterior cortical atrophy.