H2BC21 and synovial sarcoma: Regarding the correlations of circulating histones with coagulation parameters, we found that in SS patients H2B and H3 showed a strong positive correlation with D-dimer (Spearman’s ρ = 0.742, p < 0.001; Spearman’s ρ = 0.519, p < 0.001, respectively), whereas both histones correlated negatively with the Quick index (Spearman’s ρ = -0.485, p < 0.001; Spearman’s ρ = − 0.385, p < 0.001, respectively).