Lastly, we confirmed expected dependencies on the p53/p21/DREAM activation axis: tumours that were proficient in TP53 or the components of the DREAM complex, as well as those with higher p21 expression, had elevated G0 arrest levels across numerous tissues (Fig. 2e, Supplementary Fig. 2g-h), although only 8 out of 139 genes in our signature are directly transcriptionally regulated by p53 [64]. This evidence concerns the gene KCNIP3 and neoplasm.