In this paper, we report on identification of BRAFV600E, CCND1, and MYC mutations in a patient with synchronous triple primary malignant neoplasms, including malignant melanoma (MM), papillary thyroid carcinoma (PTC), and clear-cell renal cell carcinoma (ccRCC). This evidence concerns the gene CCND1 and nonpapillary renal cell carcinoma.