While there was no overall group difference for TIMP-4 levels, post hoc comparisons revealed significantly lower TIMP-4 levels in the A + CU controls (1.4 ng/mL) compared to the MCI-AD patients (1.7 ng/mL, F = 7.47, df = 1, P = 0.04). The gene discussed is TIMP4; the disease is Alzheimer disease.