In the context of cholestasis-induced liver fibrosis, enriched non-coding RNA-H19 (LncRNA-H19) carrying EVs released from cholangiocytes can be internalized by both hepatocytes and HSCs, where they promote liver injury by down regulating small heterodimer partner (SHP) and increasing ECM formation [38, 39]. This evidence concerns the gene NR0B2 and cholestasis.