RGS1 and acute respiratory distress syndrome: MiR-223 and miR-27b-3p transferred respectively by secreted EVs from vascular endothelial cells (EnCs) and type II alveolar epithelial cells (EpCs-II) regulate heterogeneity of alveolar macrophages by targeting regulator of G protein signaling-1 (RGS1), and thus reduce fibrosis in acute lung injury/acute respiratory distress syndrome (ALI/ARDS) and pulmonary fibrosis [148].