Interestingly, when enhancing the high selectivity of calcium signal in CTL or knocking out EGR4 in T cells (EGR4, a member of the zinc finger transcription factor family, was reported as a key regulator of T cell differentiation), IFN- γ production is increased, T cells are activated and melanoma growth is inhibited [216, 217]. Here, EGR4 is linked to melanoma.