APP and nervous system disorder: The implications of these findings for neurological disease research are manifold, e.g., the still unresolved questions of pre- or postsynaptic localization of proteins that may be altered in neurodegenerative diseases, such as amyloid precursor protein (APP) [75, 76], or huntingtin [77], or the study of the mechanisms of network anterograde transsynaptic transmission of misfolded proteins [78].