Diabetes mellitus (DM) represents a commonly serious metabolic disorder caused by either deficit in insulin secretion (type 1 diabetes mellitus, T1DM) or insulin resistance (type 2 diabetes mellitus, T2DM), among which type 2 diabetes mellitus (T2DM) accounts for approximately 90% of total cases of DM worldwide [1]. Here, INS is linked to type 1 diabetes mellitus.