RT activates multiple immune-associated pathways by damaging tumor cells, including cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase (Cyclic GMP-AMP synthase, cGAS), and stimulator of interferon genes (STING) protein (cGAS-STING pathway) [22]. The gene discussed is STING1; the disease is neoplasm.