Additionally, western blot also implied that silencing IL4I1 could suppress the level of CD206 (M2 macrophage surface marker) (Fig. 7d) and even CCL2 expression of si-IL4I1-transfected ccRCC cells (786-O and 769-P) (Fig. 5f). Here, CCL2 is linked to nonpapillary renal cell carcinoma.