Anti-inflammatory M1 macrophages [induced by interleukin (IL)-1β, IL-6, IL-12, IL-23 and Tumor Necrosis Factor (TNF)-α cytokines] accelerate the activation of adaptive immune responses to inhibit tumor growth, while pro-inflammatory and cytotoxic M2 macrophages [induced by IL-10, Transforming growth factor (TGF)-β, chemokine ligand (CCL)1, CCL2, CCL17, CCL18, and CCL22] exert immunosuppressive activities to promote protumorigenic activities [16, 17]. The gene discussed is CCL2; the disease is neoplasm.