CD4+ Th1, Th17 and Th1* cells (also referred to as Th17.1, Th1/Th17, exTh17 or Th1-like Th17 cells [6–9]) can transfer EAE and have been linked to disease onset, progression, and relapse rates also in MS [6, 10, 11]. This evidence concerns the gene CD4 and myeloid sarcoma.