In addition, the result of the colocalization analysis suggested that the three significant metabolite traits and asthma likely share causal variants within the FADS1 locus ('Ratio of bis-allylic groups to double bonds’: PP.H4 = 0.983; 'Ratio of bis-allylic groups to total fatty acids’: PP.H4 = 0.980; 'Average number of methylene groups in a fatty acid chain’: PP.H4 = 0.981, Fig. 4A–C). Here, FADS1 is linked to asthma.