As is shown in Table 2, the results after adjusting for the distribution of age, FBG, and infarction showed that the baseline NIHSS score (OR = 1.059, 95%CI:1.005 ~ 1.117, P = 0.033) and ln(NT-proBNP) (OR = 1.450, 95%CI: 1.072 ~ 1.963, P = 0.016) were the independent influencing factors of END after intravenous thrombolysis in AIS patient. This evidence concerns the gene NPPB and infarction.