Another research project extended these findings by showing that CIS inhibits vascular endothelial growth factor (VEGF)-mediated angiogenesis in MatrigelTM plugs in mice [285]. Interestingly, the inhibitory effects of CIS on HUVEC motility may proceed not only after the direct exposure, but also indirectly in a paracrine manner. The gene discussed is VEGFA; the disease is in situ carcinoma.