IFNG and tuberculosis: Regulatory T-cells (Treg) are involved in inhibiting Mtb infection control since they decrease IFN-γ production in people having active TB, even when faced with potent antigens such as Bacillus Calmette-Guérin (BCG) and ESAT-6, which could contribute to the pathogenesis of the microorganism causing the infection (Chen et al. 2007; Urdahl et al. 2011).