IRF3 and Alzheimer disease: The ratio of pIRF3/total IRF3 was also decreased (Figs. 7, S05) (AD = 0.582 ± 0.038, control = 1.131 ± 0.152, n = 11, p = 0.0030), suggesting that phosphorylation of IRF3, which is required for formation of the trimeric complex, may be inhibited in AD.