In four studies (Cisd1, Dmd, Fabp2, Zfp280d), the manual assessment already noted altered cardiac parameters, consolidated in diagnostics, and further substantiated by the concordant automated analysis and heart diseases for Dmd, Zfp280d, and Cisd1 but not completely for Fabp2, wherein the hearts still appeared to be morphologically normal in the histopathological evaluation. This evidence concerns the gene CISD1 and heart disorder.