PINK1 and Parkinson disease: Meanwhile it is also implicated in ciliogenesis through modulating interactions of RAB8A, RAB10, and RAB12 with RILPL1/2.185 Upon activation by mitochondrial depolarization, PTEN-induced kinase 1 (PINK1) phosphorylate S111 in Rab8A, which blocks Rabin8 (Rab8 GEF)-mediated Rab8A activation.186 LRRK1 and PINK1 are two important kinases in development of Parkinson’s disease (PD).