RHOA and breast carcinoma: A series of compounds screened by time-resolved fluorescence methods can block proliferation and migration of breast carcinoma cells through interrupting interactions between CDC42 and the scaffold protein IQGAP1.344 In a recent study, a covalent ligand, DC-Rhoin04, has been discovered to bind to an allosteric pocket mainly composed by switch II next to residue C107 in RHOA and inhibits migration and invasion of tumor cells.