RALA and cancer: Activation and upregulation of Rals are observed in many Ras-driven tumors, indicating the potential of Rals as cooperative targets with Ras for cancer treatments.221 In a parallel study for Ral inhibitors, two compounds, RBC8 and BQU57 from virtual screen, were found to bind to a pocket mainly composed by residues in Switch II with ~100 μM affinity.