A series of compounds screened by time-resolved fluorescence methods can block proliferation and migration of breast carcinoma cells through interrupting interactions between CDC42 and the scaffold protein IQGAP1.344 In a recent study, a covalent ligand, DC-Rhoin04, has been discovered to bind to an allosteric pocket mainly composed by switch II next to residue C107 in RHOA and inhibits migration and invasion of tumor cells. Here, CDC42 is linked to breast carcinoma.