Low expression of ARL3 in gliomas predicted poor prognosis, likely due to its essential role in angiogenesis and immune cell infiltration in the microenvironment of the cancer.254 Arf6 is involved in the accumulation of cholesterol in podocytes in diabetic kidney disease.255 Legionella pneumophila and Rickettsia prowazekii, the bacteria responsible for Legionnaire’s disease and epidemic typhus respectively, utilize a Type IV secretion system to infect target cells. This evidence concerns the gene ARL3 and central nervous system cancer.