Further, blockade of GALR signaling by M35 IP injection potently improved hyperglycemia, hyperglucagonemia, as well as glucagon-associated hepatic glycogen depletion, of streptozotocin (STZ)-treated mice with insulin deficiency45 (Fig. 5c and Supplementary Fig. S7d–g), excluding the participation of insulin. This evidence concerns the gene INS and Hyperglycemia.