One of which showed no significant associations between these two polymorphisms (rs1800947 and rs1205) in CRP genes and IS (González‐Giraldo et al., 2016), one showed scant evidence to support a role for CRP gene rs2794521 polymorphisms in ischemic stroke predisposition, (Liu et al., 2015) and one could provide the first proof that genetic variants (rs1130864 and rs2794521) within the CRP locus are associated with ischemic stroke. This evidence concerns the gene CRP and ischemic stroke.