Furthermore, MAP4K3 loss-of-function renders KO mice resistant to experimental autoimmune encephalitis, and human patients with systemic lupus erythematosus display increased expression of MAP4K3 accompanied by hyperactivation of Protein Kinase C-θ (Chuang et al, 2011, 2019). The gene discussed is MAP4K3; the disease is systemic lupus erythematosus.