Moreover, a number of the largest fold changes in ubiquitinated proteins in the CCNFS621G motor neurons (Table 1) were in ALS-associated proteins, including DCTN1, ENO2, INA, MAP6 and the more recently associated STMN2, further suggesting a direct role of CCNF in modulating the ALS protein network (55). Here, CCNF is linked to amyotrophic lateral sclerosis.