Although the majority of sporadic ALS and FTD cases have inclusions that are immunoreactive for TDP-43 (32–34), SOD1 and FUS familial ALS cases are associated with the deposition of SOD1 and FUS, respectively, and show no immunoreactivity for TDP-43 (35). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.