In the research by Zhang et al., it was found that GSKJ4 exerted an inhibitory effect on breast cancer stem cells by inhibiting the activities of histone demethylation metastasis KDM6A (UTX) and KDM6B (JMJD3), with the potential to be used as a targeted therapy for breast cancer.376. The gene discussed is KDM6B; the disease is breast carcinoma.