Similar to the unique anti‐cancer mechanism of HBO1 in AML, SETDB1 shows a lower expression level in AML, while the higher level of SETDB1 positively correlates with more favorable overall survival, and its mediated H3K9me3 has become an important epigenomic marker of AML.345, 346. The gene discussed is KAT7; the disease is acute myeloid leukemia.