Moreover, CB2 expression was increased in MDA-MB-231 cell treated with cisplatin, doxorubicin, and docetaxel, and sensitivity to these anti-tumor drugs was increased in BC cells overexpressing CB2.<h4>Conclusions</h4>These findings reveal that CB2 mediates BC via the PI3K/Akt/mTOR signaling pathway. Here, CNR2 is linked to breast cancer.