AKT1 and breast carcinoma: Elevated S1P will interact with S1PR1 and S1PR3 and activate PI3K/Akt, Ras/ERK, PLC/PKC and Rho/ROCK signaling pathways [13–17], which, in turn, would promote proliferation, survival, growth, migration and metastasis of breast cancer cells [13, 18, 19].