Furthermore, ceramide glycosyltransferases,an enzyme class that catalyzes the formation of hexosylceramides,has been implicated in playing a role in tumor progression.48 Overexpression of uridine diphosphate-glucoseceramide glucosyltransferase (UGCG), the gene involved in the synthesisof glucosylceramide, has also been reported in ovarian cancer cells.48 The highest abundance increase for a discriminantlipid was for HexCer(d34:1) in lifetime stage V. Finally, six SM specieswere selected in the lifetime stage V classification task, all havinglow relative abundances in DKO mice vs DKO controls. This evidence concerns the gene UGCG and ovarian carcinoma.