Gene set enrichment analysis (GSEA) and DEG analysis identified upregulation of genes involved in proliferation (MKi67, CDK1, BUB1B, CDC20), metabolism (GYS2, STC1, KIF20), adhesion (ITGA8, ICAM1, VCAN), and ECMECM(MMP9, MMP10, COL4A4) pathways in DLBCL-FRCs (Figure 4B and Supplemental Figure 5C). This evidence concerns the gene MMP9 and diffuse large B-cell lymphoma.