Confocal analysis showed that murine and human CD8+ TILs that had been cultured with IμHABcl6-FRCs or DLBCL-FRCs(p), respectively, displayed a reduced ability to form F-actin–rich, granzyme B+ (GrB) lytic synapses with tumor B cells when compared with FRC-educated TILs (Figure 8B and Supplemental Figure 7E). Here, GZMB is linked to diffuse large B-cell lymphoma.