Focusing on general differences between both phenotypes, we could observe, for example, that in treated cocultured BMS (tCBMS) astrocytes, the TGF-β–dependent IGF-binding protein 7 (IGFBP7) — a marker previously described in cerebrospinal fluid of MS patients (26) — was more strongly upregulated than in tCPMS. Here, IGFBP7 is linked to myeloid sarcoma.