Originally, LIF has been described not only as a mediator leading to differentiation in murine leukemia cells, but also as a hematopoietic stem cell–stabilizing factor (54), since its upregulation has been found in diverse models of stress, such as in bone marrow irradiation, promoting stem cell survival (55), and in spinal cord injury, promoting regeneration. The gene discussed is LIF; the disease is leukemia.