Moreover, GATA4 acts as a key zinc finger-containing transcription factor of numerous cardiac-specific genes including Nppa and Nppb [16, 24] and ablation of GATA4 by siRNAs decreased ANP expression [25], therefore PARP16 contribute to the upregulation of ANP and BNP at least partly via activating the IRE1α–sXBP1–GATA4 pathway, further promote the progress of cardiac hypertrophy. Here, NPPB is linked to cardiac hypertrophy.