Moreover, GATA4 acts as a key zinc finger-containing transcription factor of numerous cardiac-specific genes including Nppa and Nppb [16, 24] and ablation of GATA4 by siRNAs decreased ANP expression [25], therefore PARP16 contribute to the upregulation of ANP and BNP at least partly via activating the IRE1α–sXBP1–GATA4 pathway, further promote the progress of cardiac hypertrophy. The gene discussed is PARP16; the disease is cardiac hypertrophy.