Given that UPR is involved in the pathogenesis of cardiac hypertrophy [15] as well as PARP16 is correlated with the activation of the UPR sensors PERK and IRE1α [8], we examined the expressions of the PERK and IRE1α signaling in PE-treated NRCMs or H9C2 cells. Here, EIF2AK3 is linked to cardiac hypertrophy.