MLH1 and colorectal carcinoma: SSLs with dysplasia (SSLDs) represent an intermediate step between SSLs and advanced CRCs and are considered to progress to either of the following subtypes: microsatellite instable-high (MSI-H) CRC with MLH1 inactivation or microsatellite stable (MSS) CRC without MLH1 alteration [25, 31–33].