More so, two proteins — histamine-releasing factor (HRF) and the elongation factor 1α (EF-1α) — were reported to be associated with EVs of P. berghei NK-65 and were implicated with immunosuppression of CD4+ T cells during the blood stages of the parasite infection (Demarta-Gatsi et al. 2019). This evidence concerns the gene CD4 and parasitic infectious disease.