The researchers discovered that parasite oocysts with a knockdown expression of CSPmut, on infection with mosquito-induced hemocyte nitration, mediate by NADPH oxidase 5 (NOX5), which then fosters the melanization of matured oocysts, upregulated expression of hemocyte TEP1 and a corresponding distorted release of sporozoites (Zhu et al. 2022). This evidence concerns the gene NOX5 and infection.