We further explored the different distributions of major AD risk factors, including APP, microtubule-associated protein tau (MAPT) and presenilin1 (PSEN1) [1, 2, 44, 45], in SGs, and found that APP and ADAM metallopeptidase domain 10 (ADAM10) [46] were enriched in SGs and exhibited both G3BP1 and G3BP2 eCLIP-peaks (Supplementary Figure 3T). This evidence concerns the gene PSEN1 and Alzheimer disease.