TNNI3 and Sepsis: In addition, in our study, LVEF and LVFS values were not observed statistically after 12 hour of CLP induction in rats, indicating that cardiac function may not be unimpaired, which may be the result of the compensatory state of the heart in the early stage of sepsis, while it was significantly reduced after 1 day (Figure 2A–2C); H&E staining (Figure 2D) showed that the degree of cardiac tissue damage induced by CLP was serious; the serum levels of myocardial injury markers cTnI, CK, and LDH (Figure 3A–3C) were significantly increased in CLP-induced rats.