Therefore, we speculated that in CLP-induced septic rats, XBJ implementation may potentially result in inhibiting apoptosis and promoting autophagy via activating PI3K/AKT/mTOR pathway in the early stage of sepsis, as well as promoting apoptosis and inhibiting autophagy via, at least partially, suppressing PI3K/AKT/mTOR pathway in the late stage of sepsis. The gene discussed is AKT1; the disease is Sepsis.