CASP3 and Sepsis: As shown in Figure 4B, the expression of the proteins Bax, Cleaved-Caspase 3, Cleaved-Caspase 9, Cytochrome C, and Cleaved-PARP were significantly increased, whereas the expression of Bcl-2 was significantly decreased in the myocardium of rat with sepsis as compared with the Sham group at the same point of time.