The second one is that blocking the PI3K/AKT/mTOR signaling pathway had a protective effect against sepsis [26, 27], which is in line with our findings at 1d, 2d, 3d and 5d that administration of XBJ therapy suppressed p-PI3K, p-AKT and p-mTOR, showing by inhibition of the PI3K/AKT/mTOR pathway. The gene discussed is AKT1; the disease is Sepsis.