BECN1 and Sepsis: The results showed that compared with the CLP group, Beclin-1 expression was low, LC3-II/LC3-I ratio decreased, and P62 accumulation was evident at 12 h of XBJ intervention, and all data were reversed at 1 to 5 days (Figure 5), demonstrated XBJ alleviated SIMI by inhibiting autophagy in the early stage of sepsis, and enhancing autophagy in the late stage of sepsis.