AKT1 and Sepsis: The first one is that the improvement of SIMI is through the activation of PI3K/AKT/mTOR signaling pathway [63, 64], which is in line with our findings at 12h that administration of XBJ therapy increased the phosphorylation levels of PI3K, AKT and mTOR in CLP-induced sepsis, suggesting by activation of the PI3K/AKT/mTOR pathway.