MAPT and Flavivirus Infections: The association ofthe former has previously been demonstrated by ELISA, in one of theonly studies of this type.75 The role ofactin, microtubule, and intermediate filament cytoskeletal re-organizationin flavivirus infection has been described76 and upregulation of MAPT and MAP2 may represent neuronal damagefollowing transneural spread of JEV.