The identified proteins fitwell into the existing literature on the host response in JEV andother closely associated flavivirus infections, most importantly WestNile virus infection.72,73 MAPT and MAP2 are both closelyassociated microtubule stabilizing proteins specific to neuronal cells.74 Both proteins were identified in this studyas being biomarkers of JE in CSF, and the high levels in comparisonto other neurological infections are striking. The gene discussed is MAP2; the disease is Japanese encephalitis.