Similar pathways have been implicated based on snRNAseq analyses from human postmortem brain (Mathys et al., 2019; Grubman et al., 2019; Lau et al., 2020) and several mouse AD models, including MAPT transgenics (Wang et al., 2022; Lee et al., 2021; Habib et al., 2020; Zhou et al., 2020). The gene discussed is MAPT; the disease is Alzheimer disease.