We and others have also documented similar findings in AD mouse models, including both MAPT and amyloid precursor protein transgenics (Wan et al., 2020; Cummings et al., 2015; Gjoneska et al., 2015; Matarin et al., 2015; Hargis and Blalock, 2017). The gene discussed is MAPT; the disease is Alzheimer disease.