Pan-neuronal expression of either wildtype or mutant forms of the human microtubule-associated protein tau (MAPT) gene in Drosophila recapitulates key features of AD and other tauopathies, including misfolded and hyperphosphorylated tau, age-dependent synaptic and neuron loss, and reduced survival (Wittmann et al., 2001). Here, MAPT is linked to Alzheimer disease.