IFNG and type 2 diabetes mellitus: To bridge this knowledge gap, we first evaluated the expression changes of selected T2D-related lncRNAs in an in vitro model of pro-inflammatory macrophage activation, by stimulating the human leukemia monocytic cell line, THP-1, to macrophage-like cells (M (-)) and then to pro-inflammatory macrophage-like cells (M (IFN-γ/LPS)), as described in the Materials and Methods Section (Figure 4A).