In the present study, we examined the anti-tumor effects of the IFN-inducible chemokines CXCL9, CXCL10, and CXCL11 by generating stably expressing cell lines in which the genes for the three IFN-inducible chemokines were introduced into a mouse squamous cell carcinoma (SCC) cell line and transplanted into nude mice. This evidence concerns the gene CXCL9 and squamous cell carcinoma.